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It is not intended to provide medical or other professional advice. Tina Huang is a well-known data scientist who has over 10 years of experience on YouTube and has previously worked at a FAANG organization. Jnsson, H., Ginolhac, A., Schubert, M., Johnson, P. L. F. & Orlando, L. MapDamage2.0: fast approximate Bayesian estimates of ancient DNA damage parameters. Write a sharp and effective resume in minutes and get noticed by employers. Sci. Leveraging the substantially increased sample size, we investigated genetically distinct hunter-gatherer groups for allele frequencies at selected loci that are known to be associated with specific phenotypic traits in present-day Europeans (Fig. Front. E.A. The course you are purchasing is still hosted by 365 Data Science and comes with most of the perks of our dedicated platform resume builder, user dashboard, Q&A hub, and more. In other words, youll never have to worry about validity issues or having to re-take the course after a certain amount of time. I'm a data scientist and youtuber. TV Actresses. Subsequently, I worked in . The y axis shows the average of calibrated radiocarbon dates in thousands of years (kyr) (Supplementary Data 1.A). b, Population diversity shown by PMR between individuals in different groups. Dismiss. Thats exactly why choosing the right feature to build is so important! Nature thanks Marta Mirazn Lahr, Ludovic Orlando and the other, anonymous, reviewer(s) for their contribution to the peer review of this work. Curr. Riddle Solved: Why Was Roman Concrete So Durable? Find contact's direct phone number, email address, work history, and more. Notably, and contrary to the report by Fu et al.4, another Gravettian-associated population from centralwestern Europe (Goyet in Belgium, n=6 individuals) is both geographically and genetically intermediate between the Vstonice and Fournol clusters. (2023, March 1). Sep 2017 - Aug 20181 year. Dabney, J. et al. S. Shnaider received support from theRussian Science Foundation (no. Genome Biol. An expert in the industry, and a tireless advocate for improving it, Areej AbuAli is an inspiring person for those in the SEO space. The mitochondrial haplogroups were determined using HaploGrep 295, based on the consensus sequences generated from Schmutzi inspected for each sample at increasing quality filters (from q0 to q20). Youll be surprised how much value there is in a quick XGBoost model, for example. Nucleic Acids Res. CAS Using DATES software, we estimated the admixture between Villabruna/Oberkassel and ANE ancestries in these old Sidelkino-cluster-related individuals to around 1513ka (Extended Data Fig. Gnther, T. et al. The triangles show the average calibrated dates of the tested groups and the dots show the estimated admixture dates with the software DATES105 using Oberkassel (red dots) or Villabruna (blue dots) clusters as one source and ANE-related individuals as the other source population. The analysed genomes also show that the descendants of these Epigravettian inhabitants of the Italian peninsula spread across the rest of Europe about 14,000 years ago, replacing populations associated with the Magdalenian culture. and D.C. have received funding from the Italian Ministry of University and Research (MUR) PRIN 2017 grants 20177PJ9XF and 20174BTC4R_002. This results in a tree with 57 newly reported and previously published ancient individuals while present-day sequences are collapsed in the major Y-chromosome haplogroups (the most basal lineages are not shown). The previous inhabitants may have migrated to the north as their habitat, the 'mammoth' steppe, dwindled," says Johannes Krause, the study's senior author. The data here can also be structured or unstructured. Mid and Late Upper Palaeolithic in the Adriatic Basin: chronology, transitions and human adaptations to a changing landscape. Sci. tina huang data science Explained in Instagram Photos. An improved, lightweight and secure authentication scheme in context of fog-centric IoT communication is proposed in this paper to eradicate all the above mentioned security shortfalls of Wajid et al scheme. 6 Reasons We Just Cant Stop. Population genomics of Mesolithic Scandinavia: investigating early postglacial migration routes and high-latitude adaptation. Thisancestry profile survived during the Last Glacial Maximum (25,000 to 19,000 years ago) in human populations from southwestern Europe associated with the Solutreanculture, and withthe following Magdalenian culturethat re-expanded northeastward after the Last Glacial Maximum. Genetics and material culture support repeated expansions into Paleolithic Eurasia from a population hub out of Africa. The Kostenki genetic signature (related to the Kostenki 14 genome, and hereafter referred to as the Kostenkicluster or ancestry) contributed to the later Vstonice genetic cluster(hereafter,Vstonice cluster or ancestry), named after the Doln Vstonice site in Czechia4. In our interview with Tina Huang we were told the story of a student who wanted to learn to code. 6, 16581668 (2022). An early modern human from Romania with a recent Neanderthal ancestor. Genetically, however, the populations from western and southwestern Europe (today's France and Iberia) differed from contemporaneous populations from central and southern Europe (today's Czech Republic and Italy). If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. Piezonka, H. et al. Currently use of the word 'vape' now means "to inhale and exhale the vapor produced by an . 116, 105100 (2020). Admixture events were dated using the ancestry covariance pattern-based DATES 753 program105, with a bin size of 0.1 cM for covariance calculation and the start of exponential fitting at d0.5cM. 7, eabd6535 (2021). S.T. Max Planck Institute for Evolutionary Anthropology. Pleistocene North African genomes link Near Eastern and sub-Saharan African human populations. I am super excited to join the 365 Data Use Cases series, and in this post, I will share insights about my favorite data use case: product development. After DNA lysis, a subset of samples was extracted using silica-coated magnetic particles on an automated liquid handling system (Agilent Technologies Bravo NGS Workstation)57. For ds_halfUDG libraries, we masked 2bp from both ends of the reads with trimBam in bamUtil 1.0.13 (https://github.com/statgen/bamUtil) to remove the damaged sites. Finally, unsupervised clustering and more complex techniques, such as deep learning, also have their place. 27, 576582 (2017). & Strimmer, K. APE: analyses of phylogenetics and evolution in R language. Curr. . Tina Huang is a statistician who focuses on the statistical modeling and analysis of big data. Protoc. The human remains were processed in dedicated laboratories at the Max Planck Institute for the Science of Human History in Jena (Germany), University of Tbingen (Germany), University of Florence (Italy), Leiden University Medical Center (the Netherlands) and University of Tartu (Estonia). Weissensteiner, H. et al. Ecol. She is concise, pragmatic and to the point in the videos and it is easy to follow her lectures. Ice Age survivors. Double-stranded DNA libraries were built from 25l of DNA extract, without the presence of uracil DNA glycosylase (ds_nonUDG) or in the presence of uracil DNA glycosylase (ds_halfUDG), following a double-stranded UDG-half library preparation to reduce, but not eliminate, the amount of deamination-induced damage towards the ends of ancient DNA (aDNA) fragments58. Interactions between people from central and eastern Europe can only be detected again from 8,000 years ago. The genomic history of southeastern Europe. For contaminated libraries we used the PMD-filtered bam files as the input for genotyping. Genetic ancestry changes in Stone to Bronze Age transition in the East European plain. The Solutrean culture is temporally intermediate between the Gravettian and the Magdalenian (or the Badegoulian) cultures, and is found in southwestern and western Europe, which are considered to have been climatic refugia for human populations during the LGM25,26. 2022 Fab Business Solutions - All Rights Reserved. Cardiff, Wales, United Kingdom. Furthermore, the findings show that there had been no genetic exchange between contemporaneous hunter-gatherer populations in western and eastern Europe for more than 6,000 years. H. Rougier and I.C. Nat. View Tina Zhang's business profile as Brand Specialist at Dymind Biotechnology. Learn in-demand skills with a structured course that prepares you for the world of data science as it is today. 14 following. All enrolled students have access to course exams no matter how many lessons they have watched in a course. Ecol. J. Archaeol. These data cover a time span of around 30,000 years from the Upper Palaeolithic to the Late Neolithic (defined here by the presence of pottery rather than by farming subsistence economy if not indicated), derive from multiple prehistoric cultural contexts, and originate from 54 archaeological sites in 14 countries: 1 Aurignacian-associated individual from Belgium and 1 culturally unassigned individual from Romania (3533ka), 15 Gravettian-associated individuals from Spain, France, Belgium, Czechia and Italy (3126ka), 2 Solutrean-associated individuals from Spain and France (2321ka), 9 Magdalenian-associated individuals from France, Germany, and Poland (1815ka), 4 Epigravettian-associated individuals from Italy (1713ka), 2 Federmesser-associated individuals from Germany (14ka), and 81 Mesolithic to Neolithic foragers from across western Eurasia (115ka), together with 1 central Eurasian Neolithic individual from Tajikistan (8ka) (Fig. Modern humans left sub-Saharan Africa at least 60 thousand years ago (ka), and during their initial expansion into Eurasia, they genetically mixed with Neanderthals, resultingin 23% Neanderthal ancestry in the majority of present-day non-African populations5. After 2 washing steps using the manufacturers wash buffer, DNA was eluted in TET (10mM Tris, 1mM EDTA and 0.05% Tween) in two steps for a final volume of 100l. Yang, M. A. et al. In practice, we use machine learning in different conjunctures. Fu, Q. et al. Tina Huang, a former engineer at Apple, Google, and Twitter, explains why she started API management startup Transposit. Its the complexity of product development, with all of its moving parts, that makes data immensely powerful. Tina Llorca CPA, CWP, CEPP, CIS, MDRT Ampliar bsqueda. The ancient human specimens analysed in this work derive from multiple scientific collaborations. Wood, R. E. et al. Echinacea. This might also explain the genetic uniformity of the Oberkassel cluster across large parts of western Eurasia but genomic data from between 15 and 14ka is needed to understand the exact dynamics of this turnover. Upper Palaeolithic Siberian genome reveals dual ancestry of Native Americans. Echinacea, also known as Coneflower, is legendary for a reason: science has shown multiple species of Echinacea can provide potentially broad-reaching support for the innate and adaptive immune system. This was achieved through collaboration with local curators and scientists from the countries where the skeletal material is preserved and who are listed among the authors of this study. Negative and positive controls were carried alongside each experiment. "With these findings, we can for the first time directly support the hypothesis that during the Last Glacial Maximum people found refuge in the climatically more favourable region of southwestern Europe" says first author Cosimo Posth. What is surprising is that the Code Cup was so popular that Stanford decided to throw open a Data Science Week in which anyone can submit a code challenge to the top 200 submissions. 6 West Eurasian PCA showing the genetic positioning of post-LGM hunter-gatherers. In anticipation of possible near-term approval from the US Food and Drug Administration for renal denervation, there must be an insistence on longer-term clinical outcomes and safety data. 7,794 followers. In the MDS plot, we find that all of the newly and previously reported Epigravettian-associated individuals fall within the Villabruna cluster4 (Fig. Now we have the founder and CEO of YSYS, Deborah Okenla. The generation time is set to 29 years and the error bars show the SE of the admixture date estimated from jackknife resampling (n=22 autosomal chromosomes). First, I like it because of how powerful (almost magical) it is in driving decisions. . Rep. 11, 15005 (2021). Google Scholar. Hi! Get the latest science news in your RSS reader with ScienceDaily's hourly updated newsfeeds, covering hundreds of topics: Keep up to date with the latest news from ScienceDaily via social networks: Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Third, Magdalenian-associated individuals not only from Iberia but also from the rest of Europe carry Epigravettian-associated ancestry (Villabruna cluster). In product development, we do lots of opportunity sizing to decide which features to build and what opportunities to invest in. Other individuals from that period, such as Zlat k from Czechia and UstIshim from Russia, do not carry significantly more Neanderthal ancestry than other non-African groups1,7, indicating differential interactions between Neanderthals and early modern humans during their initial expansions across Eurasia. Dotted lines delimit geographic regions described in the text. Paradis, E., Claude, J. 9 Graphical summary depicting the main genetic transformations in post-40 ka hunter-gatherers from Europe. We then attempted to model 250 published and newly reported hunter-gatherers dated to 145ka using qpAdm as a mixture of Oberkassel, Sidelkino, GoyetQ2 ancestries, and an ancestry maximized in Anatolian Neolithic farmers (ANF), as a considerable portion of the sequenced hunter-gatherer genomes date after around 8ka, when ANF ancestry started spreading across Europe. Her main topic is AI, exploring how it works and, most interestingly, how we increasingly interact with it in the world. Don't be shy, get in touch. Dr. Huang received her BS degree in Chemistry from Bethel College and her PhD in Analytical Chemistry from the University of Kansas in 1998. Note added in proof:A companion paper51describes genome-wide data of a 23,000-year-old Solutrean-associated individual from southern Iberia that extend the evidence of genetic continuity across the LGM in southwestern Europe. Follow a proven methodology, discover how to avoid common mistakes and impress employers as the best person for the job. Amazing content! Archaeological background, method descriptions and discussions additional to the main text, including sections 113, Figs. Biol. On the basis of the genetic variation of present-day Europeans, this could imply phenotypic differences between post-14ka hunter-gatherer populations across Europe, with individuals in the Oberkassel cluster possibly exhibiting darker skin and lighter eyes, and individuals in the Sidelkino cluster possibly lighter skin and darker eye colour. Author pages are created from data sourced from our academic publisher partnerships and public sources. Surprisingly, however, none of those pre-40ka individuals left substantial traces in the genetic makeup of present-day Eurasian populations1,2,6,7. The x-axis shows the average age of each tested individual/group and the y-axis shows the proportion of Sidelkino ancestry, relative to the total hunter-gatherer ancestry (Oberkassel + Sidelkino) in each group. The detailed grouping of individuals shown with empty coloured circles is described in Supplementary Data 1.I. The two 14ka Oberkassel individuals mark the earliest presence of WHG ancestry north of the Alps, which we therefore rename the Oberkassel cluster(hereafter, Oberkassel cluster or ancestry), using the name of the oldest reported individual to date carrying such ancestry with more than one-fold coverage, for consistency4. Fab Business Solutionsis a ProfessionalNewsPlatform. 5, 820825 (2021). Limits of long-term selection against Neandertal introgression. 2932 and Supplementary Table 4). received support from the Estonian Research Council grant PUT (PRG243). 7 Admixture dates between Oberkassel/Villabruna and ANE ancestries in the oldest individuals from the Sidelkino cluster. In this period, the Oberkassel-ancestry admixture spread further east, reaching Samara by around 6.5ka, and an increase in Sidelkino ancestry was detected in hunter-gatherers from the Baltic region, which was previously associated with the transition from the Narva culture to the Comb Ceramic culture38,39 (Extended Data Fig. 12). Our results show that the contact zone and the admixture patterns betweenthe Oberkassel and Sidelkino ancestries changed over time (Fig. Nat. Revise SQL essentials, improve your communication style and tackle the most challenging follow-up questions with ease. Citations 52. 17, 60 (2016). Proc. We further tested whether individuals included in the Vstonice and Fournol clusters share similar allele frequencies with the main representatives of those two clusters. YSYS stands for Your Startup, Your Story and is dedicated to connecting diverse people with opportunities in tech.. Late Pleistocene human genome suggests a local origin for the first farmers of central Anatolia. Newsletter, 1999 - 20001 year. The MDS analysis showing the genetic affinity among European hunter-gatherers was based on the distance matrix derived from outgroup f3-statistics, in the form 1f3(Mbuti.DG; pop1, pop2) and performed with classical MDS algorithm (cmdscale) implemented in R 3.5.1. ADS This article reviews qualitative and quantitative studies related to the academic achievement of youth from immigrant Chinese families. Evol. 5). We love meeting interesting people and making new friends. Biol. Conversely, the ancestry found in pre-30ka eastern European individuals (Kostenki cluster and Sunghir group) contributed to Gravettian-associated individuals from central and southern Europe (Vstonice cluster), the latter without descendantsretrieved in post-LGM populations from those regions. 1c). In other cases, you may have to create a more complex database structure (such as SQLite). Further palaeogenomic studies on Upper Palaeolithic individuals from the Balkans will be essential for understanding whether southeastern Europe represents the source of the Villabruna ancestry and a climatic refugium for human populations during the LGM. After the LGM, a genetic component distantly linked to the Goyet Q116-1 individual from Belgiumdated to 35 kanamed GoyetQ2 ancestry(hereafter, GoyetQ2 cluster or ancestry)reappeared in individuals from southwestern and central Europe associated with the Magdalenian culture (1914ka from Iberia to eastern Europe across central Europe) and in an admixed form in subsequent Final Palaeolithic and Mesolithic hunter-gatherers4,14, but the geographic extension of this ancestry is still unclear. I have an undergraduate degree in . and T. Saupe received support from the European Union through the European Regional Development Fund (project no. The compiled genotype file used for analyses, including re-genotyped published genomes, has been uploaded at the Edmond Data Repository of the Max Planck Society (https://edmond.mpdl.mpg.de/dataset.xhtml?persistentId=doi:10.17617/3.Y1KJMF). The three squares highlight Baltic HG groups associated with the Comb Ceramic Culture (CCC) that show a marked increase in Sidelkino-related ancestrycompared to olderBaltic HG groups. ScienceDaily. Shes also the creator of the Microsoft Excel spreadsheet Data Mining 101. She has also published a book titled Data Science: Principles and Practices which she wrote with co-author Dan Ariely. Utilized python and R on high performance computing Linux cluster to discover 3 new cancer mutations. This affinity is even stronger towards Epigravettian-associated individuals from western and central Italy and Sicily (group 2 and group 3, respectively) than to those from northern Italy (group 1) (Supplementary Data 2.F). Conversely, individuals in the Sidelkino cluster are genetically closer to AG3 than Tutkaul 1. Genome of Petera Muierii skull shows high diversity and low mutational load in pre-glacial Europe. ), no. Sign up for the Nature Briefing newsletter what matters in science, free to your inbox daily. 4a). We explain it all step-by-step, including how to download and install the necessary software, e.g., Excel, Anaconda, Jupyter Notebook, Python, R, MySQL, Tableau Public, etc. Hi, my name is Tina and I'm a data scientist at a FAANG company. Error bars show 1s.e.m. Sci. Karmin, M. et al. Tina Llorca CPA, CWP, CEPP, CIS, MDRT Expand search. 5 and Extended Data Fig. Moreover, two of the oldest published groups from western Russia belonging to the Sidelkino clusterPeschanitsa (13ka)43 and the newly reported Minino individuals (11ka)showed extra affinity to the Oberkassel cluster, possibly owing to variability in this ancestry proportion during the initial formation phase of the Sidelkino-ancestry profile. Cassidy, L. M. et al. This is also supported by f4-statistics of the form f4(Mbuti, Fournol 85; Sunghir, test), which are significantly positive for all the individuals included in the Vstonice cluster (Supplementary Data 2.B). Dots are maximum likelihood estimates and error bars show 95% confidence intervals of the derived allele frequencies (n, the number of individuals in each group, is provided in Supplementary Data 3.G). Genet. Thats it for today. This may have prompted people from the south to expand their habitat. Meet Tina Huang. A.G.-O. But she came up with a way to break down the code and create a website that she was proud of. Populations headed south? eLife 11, e77625 (2022). Ace the SQL part of any data science job interview and get hired. Nature 524, 216219 (2015). 5b and Supplementary Figs. Antonio, M. L. et al. The responsible co-authors for the material from each archaeological site are listed in Supplementary Information, section 1. In addition to this general data science content, Tina teaches SQL . Mathieson, I. et al. After 7.5ka, as ANF ancestry had reached regions north of the Alps, individuals carrying a hunter-gatherer genetic profile were primarily restricted to the northern fringes of Europe (Fig. Liet. Hi, my name is Tina and I'm a data scientist at a FAANG company. A phylogeographic reconstruction of different lineages carrying this ancestry further suggests its entry point into northeastern Italy from the Balkans followed by a north-to-south expansion into the Italian peninsula alongside a population decline through sequential bottlenecks. Emergence of human-adapted Salmonella enterica is linked to the Neolithization process. Villalba-Mouco, V. et al. & Ringbauer, H. hapCon: estimating contamination of ancient genomes by copying from reference haplotypes. English company number 3898053New York | Boston | Chicago | Austin | Toronto | Brighton | London | Copenhagen | Berlin | Stuttgart | Frankfurt | Paris | Madrid | Budapest | Sofia | Chennai | Singapore | Sydney | Melbourne. At this startup dedicated to b2b marketing, we, the data team formed by 2 people, are organizing all the data from zero and looking for their real value. All remains were sampled with the approval of the institutions responsible for the analysis of archaeological material. We built a Maximum Parsimony tree with 103 mtDNA sequences plus an African sequence as the outgroup (not shown) after the removal of individuals younger than 6.5ka and mtDNAs from the same site with an identical placement. Xiamen Guansheng Precision Machinery Co Ltd is a company integrating R&D, production and sales. Created by DataSciencePR. 39, msac017 (2022). Gronenborn, D. in The Spread of the Neolithic to Central Europe (RGZM, 2010). Biotechniques 59, 8793 (2015). The resulting GoyetQ2 cluster includes individuals spanning from western France to Poland in the period between 18 and 15ka. USA 111, 22292234 (2014). Photo by Sara Kurfe on Unsplash 1. and H. Ringbauer developed the contamination-estimation method. Nucleic Acids Res. The levels of contamination from modern human DNA were estimated on the basis of mitochondrial DNA (mtDNA), X chromosome and autosomal DNA, and with a haplotype copying model that is extended here to autosomal data in runs of homozygosity (ROH) (Methods, Supplementary Information, sections2 and 3, Supplementary Figs. 211 and Supplementary Table 1). How to Become a Data Scientist at FAANG (Ft. Tina Huang) In this video, I had the opportunity to talk with Tina Huang, a Data Scientist at one of the FAANG companies. Hunter-gatherers carrying an admixed WHG/EHG genetic profile have been sequenced from various regions of northern and eastern Europe, raising the question of how these two types of ancestries formed and interacted with each other through time and space37,38,39,40. These results show that some, but not all, of the genomic ancestries present in Europe between around 40ka and 30ka survived in the Gravettian-associated populations studied so far. This channel is about data science, learning, and productivity. In addition to her rich experience, including bioinformatics cancer research at OICR, Tina is a . The Gravettian culture was one of the most widely distributed Upper Palaeolithic cultures across western Eurasia before the LGM19. Article The PCA was carried out by smartpca in EIGENSOFT 6.0.1102, with modern individuals used for calculation and all the ancient individuals projected on the calculated PCs. A 5700 year-old human genome and oral microbiome from chewed birch pitch. 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