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Then your body uses that iron to make hemoglobin and RBCs. However, since peoples bodies react so differently to drugs, they often have to change their stance on certain drugs. Injectafer and Venofer are both brand-name drugs. Reblozyl is a brand-name prescription medication used to treat anemia in certain blood disorders. Learn how to store and discard medical supplies safely. There are currently no generic forms of either drug. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Consult your pharmacist or local waste disposal company. If you have a severe allergic reaction to Injectafer after youve left the medical facility where you received your dose of the drug, call your doctor right away. Brandon ColbyMD, a medical expert specializing in preventive medicine and clinicalgenomics. These include: Note: For more information about the potential negative effects of Injectafer, see the Injectafer side effects section above. In one study, people were given either Injectafer or an iron replacement drug called Venofer. Venofer is not for treating other forms of anemia not caused by iron deficiency. This information should not be used to decide whether or not to take Venofer or any other medicine. In the first group, some people continued taking iron by mouth, while other people took Injectafer. Otherwise, call a poison control center right away. There may be drug take-back programs in your area. This is why they have a programcalledMedWatchthat encourages Americans to report adversereactions. But for most people whove developed hypophosphatemia with Injectafer, the condition resolved within 3 months. fever, cold or flu symptoms (sore throat, cough, stuffy nose, sneezing); bruising or irritation where the medicine was injected. Injectafer is approved to treat iron deficiency anemia (IDA). In this group, after 35 days of treatment: Effectiveness of Injectafer compared with a different IV iron product. But some people have a delayed allergic reaction to certain drugs. No, you most likely wont take Injectafer long term. If a person does not have an allergic response or any other unanticipated reactions, a doctor will administer the remaining iron. Its important to note that youll get Injectafer doses from a doctor or healthcare professional in a medical facility. Feraheme also comes as a liquid thats given by IV infusion. taste impairment. Youll receive doses of either drug by a healthcare professional at a medical facility. *Patients are calculated based on an estimated annual cumulative dose. But its only approved for use in people with CKD who may or may not need dialysis. Venofer can be given as a maximum of 200mg not more than 3 times per week; doses must be 24 hours apart. Call your doctor for instructions if you miss an appointment for your Venofer injection. Symptoms of a severe allergic reaction can include: Because of the risk of allergic reaction with Injectafer, your healthcare professional will monitor you for at least 30 minutes after you get each dose of the drug. But its not known whether this poses any risk to a child whos breastfed. These effects typically last between 7 and 11 hours. Its not known whether its safe to breastfeed while youre taking Injectafer. I'm contemplating getting infusions again but I've always been a bit worried that they could cause issues in the long run. Venofer (iron sucrose injection, USP) Rx Only DESCRIPTION Venofer (iron sucrose injection, USP) is a brown, sterile, aqueous, complex of polynuclear iron (III)-hydroxide in sucrose for intravenous use. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Your doctor will recommend whether you should stop taking your multivitamin or any other supplements. This information is not specific medical advice and does not replace information you receive from the healthcare provider. The following information is provided for clinicians and other healthcare professionals. For example, if someone takes 100 mg of a drug, only half of it will be in the bloodstream in a couple ofhours. Daiichi Sankyo, Inc., the manufacturer of Injectafer, offers a program called injectconnect, which may help lower the cost of the drug. Its caused by your body not having enough iron, which is needed to make hemoglobin. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: These are not all of the side effects that may occur. Iron sucrose can make it harder for your body to absorb iron medications you take by mouth. In order for your body to make RBCs, your bone marrow needs a hormone called erythropoietin (EPO). Yes, in some cases it may. Your dosage and length of treatment are based on your medical condition, age, and response to treatment. With slow IV injection, the drug is given as a single, slow injection into your vein. It's a more immediate treatment than supplements or dietary changes. Some products that may interact with this drug include: vitamin products, other iron-containing products. This medication passes into breast milk. If you need to store Venofer at home, talk with your doctor, nurse, or pharmacist about how to store it. With IV infusion, the drug is given as a slow drip into your vein over a period of time. Injectafer contains the active drug ferric carboxymaltose, while Feraheme contains the active drug ferumoxytol. These are not all the side effects that may occur; contact your healthcare provider if you have questions. Total cumulative Venofer dose = number of 100mg ampoules for Hb increase. It depends. For instance, someone with lowblood pressuremay receive a medication to prevent migraines that lowersblood pressure, this may causeseriousside effects. You will need frequent medical tests to help your doctor determine how long to treat you with Venofer. It can also cause skin irritation and redness. And these two doses need to be separated by at least 7 days. Feraheme is also approved to treat IDA in adults who either didnt have improvement in their IDA or had side effects with iron treatment thats taken by mouth. Below are examples of these side effects. If youre wondering how longside effectslast, youll be happy to know they can last just a few hours. Mild side effects of Injectafer can include:*. You may report side effects to FDA at 1-800-FDA-1088. On day three I had a headache and felt heavy/exhausted, which lasted a few days. You may report side effects to FDA at 1-800-FDA-1088. Iron sucrose injection has a molecular weight of approximately 34,000 - 60,000 daltons and a proposed structural formula: For example, some people with anemia have extreme fatigue (lack of energy), which can make it hard for them to exercise. Side effects: DayQuil can cause side effects such as drowsiness, dizziness, nausea, vomiting, and stomach upset. However, be sure to take the dosage your doctor prescribes for you. Tell your doctor if you are taking iron supplements or other iron-based oral medications. Call 911 if your symptoms feel life threatening or if you think youre having a medical emergency. So you wont pick up this medication from a pharmacy. Venofer may reduce the absorption of iron preparations taken by mouth. Youll receive doses of Injectafer from a healthcare professional at a medical facility. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. And this could lead to weight gain, if they increase their food intake. If you need financial support to pay for Injectafer, or if you need help understanding your insurance coverage, help is available. This could happen because Injectafer helps increase their hemoglobin levels, but it doesnt address the underlying cause of their anemia. Here's some detail on certain side effects this drug may cause. In the studies, peoples hemoglobin level was measured to check for improvement in their anemia. Iron is a vital mineral in the body, central to transporting oxygen around the body in the hemoglobin. It is important to get each dose of this medication as scheduled. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. With IDA, you have anemia (low red blood cell level) thats due to not having enough iron in your body. Symptoms of overdosage include drowsiness, mental confusion, dizziness, diarrhea and vomiting etc. But you likely wont feel the drug working inside of you. Patients with iron-deficiency anemia who are having high blood loss surgery (> 500 ml) within the next 2 months and need to replace iron quickly. If you have diarrhea while youre taking Injectafer, call your doctor. Iron-refractory iron deficiency anemia (IRIDA) is a genetic form of anemia. How long it takes for the bodyto break down the meds matters and some peoples bodies simply take longer than others. Injectafer comes as a liquid thats given by either intravenous (IV) infusion or slow IV injection. If this happens, you may need to get another treatment course of Injectafer, if your doctor recommends it for you. You may also need to monitor your blood pressure at home. Its FDA-approved to treat iron deficiency anemia (IDA) in adults. And if you dont have an allergic reaction to your first dose of a drug, its typically safe to assume you wont have an allergic reaction to doses that follow. Many patients with kidney disease cannot get enough iron from food and require injections. Cholesterolmedication may reduce the risk of a stroke but it can decrease the quality of life for some people but causingweight gain, dizziness, nausea, and musclepain. This is why the FDA hasa programcalledMedWatchthat encourages Americans to report adversereactions. Potential side effects that are usually mild may include, but are not limited to: Headache Nausea Dry Mouth Stomachache Dizziness Diarrhea Constipation These side effects may not impact life too much and may only be temporary. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Venofer. Your doctor will be able to see how Venofer is working by reviewing your blood tests. TheNational Instituteof Health (NIH) and the U.S.Food and Drug Administration(FDA) monitor the side effectsof new and approved medications to ensure safety. Laboratory tests (such as complete blood count, ferritin, transferrin, total iron binding capacity-TIBC) should be performed periodically to monitor your progress or check for side effects. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time. Once inside your body, ferric carboxymaltose releases iron into your system. These lists contain up to 10 of the most common mild side effects that can occur with Injectafer, with Venofer, or with both drugs (when taken individually). fluid retention, especially in your arms, legs, or feet, people who took Feraheme had their hemoglobin level increase, on average, by 1.38 grams per deciliter (g/dL), people who took ferric carboxymaltose had their hemoglobin level increase, on average, by 1.63 g/dL, having strange cravings to eat items that arent food, such as ice, people who took Injectafer had their hemoglobin level increase, on average, by 1.6 grams per deciliter (g/dL), people who kept taking iron by mouth had their hemoglobin level increase, on average, by 0.8 g/dL, people who took Injectafer had their hemoglobin level increase, on average, by 2.9 g/dL, people who took the other intravenous iron product had their hemoglobin level increase, on average, by 2.2 g/dL, people who took Injectafer had their hemoglobin level increase by an average of 1.1 g/dL, people who took Venofer had their hemoglobin level increase by an average of 0.9 g/dL, cannot tolerate or have shown a poor response to oral iron, or, have been diagnosed with chronic kidney disease (CKD) that is non-dialysis dependent. (Hemoglobin is a protein thats found inside your red blood cells.). This includes people who: Usually, hypophosphatemia doesnt cause symptoms. Together, you and your doctor can discuss the benefits and risks of treatment options for anemia. Properly discard this product when it is expired or no longer needed. Iron infusions are given directly into a vein. (For more information on Venofer, see the Injectafer vs. Venofer section above). (A medication class describes a group of drugs that work in the same way.). Its not known if Injectafer is safe to use during pregnancy. Infusions should be administered over at least 15 minutes. Last reviewed . This survey is being conducted by the WebMD marketing sciences department. Both of theseside effectscould worsen depression and lead tolife-threateningconsequences. Dr. Colby is alsothe Founder of Sequencing.com and the authorofOutsmart Your Genes. Source: Wolters Kluwer Health. This medication is given by injection into a vein as directed by your doctor. Side effectswill last a very long time if the cause of them is not resolved. People with IDA have low blood levels of hemoglobin. "The most common side effects to COVID vaccines include pain at the injection site, fevers, chills, nausea, headaches, tiredness, and painful or swollen lymph nodes in the arm where the vaccine. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. Drug interactions may change how your medications work or increase your risk for serious side effects. Theyll do this by checking certain blood tests. dizziness. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Is the ketogenic diet right for autoimmune conditions? Examples of other drugs that may be used to treat IDA include: Your doctor will recommend the drug thats right for you depending on the severity of your anemia and any other medical conditions you may have. However, side effects at the 150 mg dose may indicate that you might not . An example of a drug interaction that many people are not aware of isgrapefruitjuice and statins. For more information about Injectafers approved uses, see the section Injectafer uses below. Does Venofer Vial interact with other drugs you are taking? He is an Affiliate Specialist of the American College of Medical Genetics and Genomics(ACMG), an Associate of the American College of Preventive Medicine(ACPM), and a member of the National Society of Genetic Counselors(NSGC). Theyll likely have you stop taking the pills while youre using Injectafer. With anemia, you have a low level of red blood cells (RBCs) in your body. I was surprised too but the Dr said it definitely sounds like a reaction. Your doctor will go over your Below are examples of these side effects. Last updated August 20, 2020. You may wonder how Injectafer compares with other medications that are prescribed for similar uses. Copyright 1996-2023 Cerner Multum, Inc. In one study, treatment with Injectafer was compared with that of iron thats taken by mouth. These are not all of the side effects that may occur. Venofer (iron sucrose) is given as an injection into the veins (intravenously or IV) by a trained healthcare provider. These lists contain examples of serious side effects that can occur with Injectafer, with Feraheme, or with both drugs (when taken individually). If either is present, do not use the liquid. One of the most commonly used tests to monitor IDA is the hemoglobin test. HRT, like other medications, does have some side effects and these are thought to be quite common. Nose or throat irritation. However, not treating iron deficiency anemia during pregnancy may cause complications such as premature birth or low birth weight. Venofer may cause significant hypotension (decreased blood pressure). Other side effects include: Common (may affect up to 1 in 10 users) Temporary taste changes (especially metallic taste) Low blood pressure or high blood pressure. We cancelled my 5th because of the reaction. Talk to your pharmacist for more details. Others last much longer (even a lifetime), which can be quite traumatizing to people. Maintain a well-balanced diet, and follow any dietary guidelines as directed by your doctor. Side effectsare uncomfortable reactions to medications or drugs. And this type of reaction is possible even if you didnt have a reaction to your first dose of the drug. Keep all regular medical and laboratory appointments. Before using, check this product visually for particles or discoloration. Symptoms include shock, dangerously low blood pressure, loss of consciousness, and/or collapse. experience severe side effects, please seek medical attention right away and notify the ordering physician. 2 0 obj But for other people, their IDA returns after treatment with Injectafer. Phosphorus is an electrolyte that your body needs in order to make energy. Your body then uses the iron from Injectafer to make hemoglobin and new RBCs. Venofer 100 mg iron/5 mL intravenous solution, Venofer 50 mg iron/2.5 mL intravenous solution, Venofer 200 mg iron/10 mL intravenous solution, Select a condition to view a list of medication options. If you have questions about drinking alcohol while youre taking Injectafer, talk with your doctor. pain in the arms or legs. This test measures the amount of hemoglobin in your blood. Keep in mind that there may be additional costs related to getting your doses of the drug at a medical facility. Venofer is used to treat iron deficiency anemia in people with kidney disease. The use of Injectafer and Feraheme in treating IDA in these adults has been directly compared in a clinical study. (IV iron is absorbed by the body more rapidly than oral iron.) Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. The researchers found that compared with their hemoglobin level before the study: But the actual price youll pay for either drug depends on your insurance plan, your location, and the pharmacy you use. 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