complex fibroadenoma pathology outlinesck3 save editor

Webpathology.com: A Collection of Surgical Pathology Images In this review, the pathology of the fibroadenoma and phyllodes tumour is revisited, with emphasis on diagnostic and management implications. 2013 Jul 12;6:267. doi : 10.1186/1756-0500-6-267 PMID: 23849288 (Free), Histopathology of fibroadenoma of the breast. Pathology. 2001 May;115(5):736-42. doi: 10.1309/F523-FMJV-W886-3J38. Printable - Juvenile Fibroadenoma - Surgical Pathology Criteria Fibroadenomas are benign while phyllodes tumor range from benign, indolent neoplasms to malignant tumors capable of distant metastasis. Schnitt: Biopsy Interpretation of the Breast, 3rd Edition, 2017, WHO Classification of Tumours Editorial Board: Breast Tumours, 5th Edition, 2019, Adenosis or lobulocentric processes with increase in glandular elements of terminal duct lobular unit (TDLU) with stromal fibrosis / sclerosis that distorts and compresses glands, Preserved 2 cell layer (inner epithelial and outer myoepithelial cells), Enlarged terminal duct lobular unit with distortion by stromal fibrosis / sclerosis, Coalescent foci of typical sclerosing adenosis, Rare; sclerosing adenosis with predominance of myoepithelial cells, presents as multifocal microscopic lesions (, Most frequent in third to fourth decades but occurs over a wide age range, Found in 12 - 28% of all benign and 5 - 7% of malignant biopsies (, Terminal duct lobular unit; otherwise, no specific location within the breast, Often an incidental finding or detected by screening, Can present as a palpable mass if nodular adenosis / adenosis tumor, Histologic examination of tissue with or without immunohistochemistry, Variable depending on the size / extent of breast involvement, If focal, may not be visualized (i.e. Indian J Pathol Microbiol. Pathology Outlines - Pseudoangiomatous stromal hyperplasia Fibroadenoma pathophysiology - wikidoc Fibroadenoma versus phyllodes tumor: a vexing problem revisited! Fibroadenoma - Libre Pathology Unable to load your collection due to an error, Unable to load your delegates due to an error. Careers. ; Cha, I.; Bauermeister, DE. Pathology Outlines - Fibroadenoma Myxoid fibroadenomas differ from conventional fibroadenomas: a - PubMed Although no significant difference was noted in patients' age and tumor size between CFA and NCFA, 5 CFA cases (33.3 %) were accompanied by the presence of carcinoma in the same breast or the contralateral breast while no NCFA cases had carcinoma in the breast. Most present in adults between menarche and menopause. Breast disease: a primer on diagnosis and management. Nigam JS, Tewari P, Prasad T, Kumar T, Kumar A. Cureus. O'Malley, Frances P.; Pinder, Sarah E. (2006). More frequent in young and black patients. The average fibroadenoma is anywhere from the size of a marble up to 2.5 centimeters (cm) in diameter. phyllodes tumour, sarcoma, pseudoangiomatous . FOIA Complex fibroadenomas were diagnosed in 63 of 401 fibroadenomas (15.7%) found at consecutive percutaneous needle or excisional surgical biopsy. document.write('' + emailE + '') Nissan N, Bauer E, Moss Massasa EE, Sklair-Levy M. Insights Imaging. Epub 2022 May 31. Percutaneous radiofrequency-assisted excision of fibroadenomas. papillary apocrine metaplasia Department of Pathology. The study included women aged 18-85 years from the Mayo Clinic Benign Breast Disease . When histopathology on core biopsy reveals a higher-risk lesion, such as atypical lobular hyperplasia, excisional biopsy may be indicated to rule out malignancy. Board review style answer #1. "Cellular" is something that can be subjective. The definitive diagnosis is made histologically by the presence . . See this image and copyright information in PMC. and transmitted securely. radial scar or papilloma) that is identified on imaging, May show enhancement on magnetic resonance imaging (, Associated with 1.5 - 2 times increased risk for subsequent breast cancer (, Risk may be slightly higher for patients with a positive family history of breast cancer (, Indicator of general breast cancer risk rather than direct precursor lesion, 30 year old woman with immature-like usual ductal hyperplasia in a fibroadenoma (, 75 year old woman with malignant phyllodes tumor with liposarcomatous differentiation and intraductal hyperplasia (, Usual ductal hyperplasia within gynecomastia-like changes of the female breast (, Proliferation of cells of luminal and myoepithelial lineages, occasionally with intermixed apocrine cells, Mild variation in cellular and nuclear size and shape, Relatively small ovoid nuclei with frequent elongated or asymmetrically tapered (pear shaped) forms, Lightly granular euchromatic chromatin and small nucleoli, Frequent longitudinal nuclear grooves (coffee bean-like) and occasional nuclear pseudoinclusions, Many examples demonstrate cellular maturation, where the cells shrink as they progress from a basal location to the center of the proliferation, becoming small and nearly pyknotic, Eosinophilic, nonabundant cytoplasm with indistinct cell borders, Cohesive proliferation with haphazard, jumbled cell arrangement or streaming growth pattern, Fenestrated, solid and occasional micropapillary patterns, Irregular slit-like fenestrations are common, especially along periphery, Cells run parallel to the edges of secondary spaces and do not exhibit a polarized orientation (this contrasts with the cells of atypical ductal hyperplasia and ductal carcinoma in situ, which have apical-basal polarity and radially orient their apical poles toward the spaces), Typically focal in a background of conventional pattern usual ductal hyperplasia, Short stubby papillae of roughly uniform height, Cytologic features of usual ductal hyperplasia, Cellular maturation present, with tips of papillae formed by tight knots of mature cells, Larger immature basal hyperplastic cells predominate or are increased beyond their usual 1 - 2 cell layers and are instead several cell layers thick, Most often encountered in fibroepithelial lesions with cellular stroma, Florid usual ductal hyperplasia can rarely demonstrate central necrosis, Typically occurs within a radial scar / complex sclerosing lesion, nipple adenoma or juvenile papillomatosis, Florid usual ductal hyperplasia within radial scars / complex sclerosing lesions can occasionally have more active appearing nuclei with mild nuclear enlargement, Other cytologic and architectural features of usual ductal hyperplasia remain intact, Sample may be moderately to highly cellular, Sheets and cohesive clusters of bland ductal cells with regular spacing and associated myoepithelial cells (, Lack of significant nuclear overlap / crowding, Ductal cell nuclei with finely granular chromatin and inconspicuous small nucleoli, Naked myoepithelial cell nuclei in the background may be present, Activating mutations in the PI3K / AKT / mTOR pathway may play a role in pathogenesis (, Round to oval nuclei with homogeneous, fine and hyperchromatic chromatin; inconspicuous nucleoli; and smooth nuclear contours, Increased amounts of pale eosinophilic to amphophilic cytoplasm with conspicuous cell borders, Cellular polarization around luminal and secondary spaces, Atypical architectural patterns formed by polarized growth (cribriform spaces, Roman arches, trabecular bars, micropapillae), Moderate nuclear enlargement throughout the proliferation, Abnormal chromatin, which may be hyperchromatic, cleared and clumped or coarsely granular, Solid epithelial proliferation showing marked expansion of multiple circumscribed duct spaces (, Thin fibrovascular cores punctuate the proliferation, with cellular palisading around the cores, Myoepithelial cells often sparse or absent along fibrovascular cores, Nuclei may superficially resemble those in usual ductal hyperplasia but demonstrate greater populational uniformity, are slightly larger and have abnormal chromatin, Often positive for neuroendocrine markers (, No change in risk compared to control populations, HMWCK mosaic positive / ER diffusely positive, HMWCK mosaic positive / ER heterogeneously positive. Only one malignancy, an invasive lobular carcinoma, was found in 63 complex fibroadenomas (1.6%). Sabate, JM. However, we cannot answer medical or research questions or give advice. This website is intended for pathologists and laboratory personnel but not for patients. At the time the article was created The Radswiki had no recorded disclosures. Dehner LP, Hill DA, Deschryver K. Pathology of the breast in children, adolescents, and young adults. Complex fibroadenomas may increase the risk of breast cancer. Pseudoangiomatous stromal hyperplasia and breast cancer risk. ; Chen, YY. Powell CM, Cranor ML, Rosen PP. Our study was to determine the select cytologic features that can accurately distinguish FA from PT. font-family: Arial, Helvetica, sans-serif; Surgical Pathology Criteria Focally, the lesion approaches the inked margin; partial lesion transection cannot be excluded. Clipboard, Search History, and several other advanced features are temporarily unavailable. abundant (intralobular) stroma usu. Fibroadenoma - Wikipedia "Radiologic evaluation of breast disorders related to pregnancy and lactation.". They fall under the broad group of adenomatous breast lesions. An official website of the United States government. NPJ Breast Cancer. (b) Ultrasound shows a well-defined oval nodule in the right axilla which was confirmed to be a fibroadenoma on core biopsy. Contact | Well circumscribed tumor with bulging cut surface, Fibroadenoma with atypical ductal hyperplasia, Sign up for our What's New in Pathology e-newsletter, Copyright PathologyOutlines.com, Inc. Click, 30150 Telegraph Road, Suite 119, Bingham Farms, Michigan 48025 (USA). Contributed by Gary Tozbikian, M.D. If it grows to 5 cm or . SIR for noncomplex fibroadenoma was 1.49 (95% CI 1.26-1.74); for complex fibroadenoma, it was 2.27 (95% CI 1.63-3.10) (test for heterogeneity in SIR, P = .02). Biphasic lesions of the breast. Pseudoangiomatous stromal hyperplasia [TI] free full text[sb], WHO Classification of Tumours Editorial Board: Breast Tumours (Medicine), 5th Edition, 2019, Schnitt: Biopsy Interpretation of the Breast (Biopsy Interpretation Series), 3rd Edition, 2017, Stanford University: Pseudoangiomatous Stromal Hyperplasia [Accessed 5 March 2020], Benign myofibroblastic proliferation simulating a vascular lesion, Usually an incidental finding but may produce palpable or mammographic mass, Complex interanastomosing spaces in dense collagenous, keloid-like stroma, Some of these spaces have spindle shaped myofibroblasts at their margins that simulate endothelial cells, Spindle cells are positive for ER, PR and CD34 but negative for other vascular markers, e.g. Home > E. Pathology by systems > Reproductive system > Female genital system > Breast > complex fibroadenoma, Complex fibroadenoma is a sub type of fibroadenoma harbouring one or more of the following features: An official website of the United States government. It is usually single, but in 20% of cases there are multiple lesions in the same breast or bilaterally. cysts larger than 3 mm. Complex fibroadenoma | Radiology Reference Article | Radiopaedia.org (PDF) Complex fibroadenoma - A case report - ResearchGate white/pale +/-hyalinization, typically paucicellular, compression of glandular elements with perserved myoepithelial cells. Epub 2021 Jul 12 doi: 10.1371/journal.pone.0253764. Kuijper A, Mommers EC, van der Wall E, van Diest PJ. ADVERTISEMENT: Supporters see fewer/no ads, Please Note: You can also scroll through stacks with your mouse wheel or the keyboard arrow keys. Federal government websites often end in .gov or .mil. 2020 Dec;53(3):439-441. doi: 10.1055/s-0040-1716187. Department of Pathology. Bethesda, MD 20894, Web Policies The myoepithelial layer is hard to see at times. Arch Pathol Lab Med. ; Hashimoto, B.; Wolverton, D. et al. Chapter 5 looks at special problems in breast cancer including bilateral breast cancer, cancer of the male breast, the unknown primary presenting with axillary lymphadenopathy, Paget's disease of the nipple-areola complex and phyllodes tumour of the breast. and Debra Zynger, M.D. Conclusion: Approximately 16% of fibroadenomas are complex. 2021 Jan 10;13(1):e12611. It is a rare benign rapidly growing breast mass in adolescent females. apocrine carcinoma breast pathology outlines We found that 15 cases fulfilled the diagnostic criteria of CFA, in which 7 (46.7 %) had an FNA diagnosis of "suspicious for malignancy" or "indeterminate" while only 2 NCFA cases had that of "indeterminate" (p = 0.004). . "Tubular adenoma of the breast: an immunohistochemical study of ten cases.". CD31, Also called pseudoangiomatous hyperplasia of mammary stroma, PASH is an incidental microscopic finding in up to 23% of breast surgical resections (, Almost always women who are premenopausal, Myofibroblastic origin, postulated role of hormonal factors (, Usually asymptomatic and an incidental finding but may be detected by imaging (, Histologic examination of resected tissue, May produce a mammographically detected mass, Nonneoplastic but mass forming lesion may rarely recur, especially in younger patients, 11 year old girl with bilateral nodular lesions (, 12 year old girl with pseudoangiomatous stromal hyperplasia (, 30 year old woman with pseudoangiomatous stromal hyperplasia of the breast with foci of morphologic malignancy (, 37 year old woman with giant nodular pseudoangiomatous stromal hyperplasia of the breast presenting as a rapidly growing tumor (, 46 year old woman with bilateral marked breast enlargement (, 67 year old man with pseudoangiomatous stromal hyperplasia of breast (, Local excision needed only in symptomatic mass forming lesions, If diagnosed on core needle biopsy, no surgical excision required, provided the diagnosis is concordant with radiologic findings (, Usually unilateral, well circumscribed, smooth nodule, Cut surface is firm, gray-white, lacks the characteristic slit-like spaces of fibroadenoma, Spaces are usually empty but may contain rare erythrocytes, Cellular areas or plump spindle cells may obscure pseudoangiomatous structure, No mitotic figures, no necrosis, no atypia, Fascicular PASH: cellular variant, in which myofibroblasts aggregate into fascicles with reduced or absent clefting, resembles myofibroblastoma, Moderately cellular with cohesive clusters of bland ductal cells (occasionally with staghorn pattern), single naked nuclei, some spindle cells with moderate cytoplasm and fine chromatin, Occasional loose hypocellular stromal tissue fragments containing spindle cells and paired elongated nuclei in fibrillary matrix (, Findings can confirm benign nature of disease but are nonspecific, resembling fibroadenoma or phyllodes tumor (, Finding plump spindled mesenchymal cells is suggestive (, Spaces are not true vascular channels but due to disruption and separation of stromal collagen fibers. We evaluated the clinical and imaging presentations of complex fibroadenomas; compared pathology at core and excisional biopsy; and contrasted age, pathology, and size of complex and simple fibroadenomas using the Student's t test. Complex fibroadenomas were diagnosed in 63 of 401 fibroadenomas (15.7%) found at consecutive percutaneous needle or excisional surgical bi-opsy. Reference article, Radiopaedia.org (Accessed on 04 Mar 2023) https://radiopaedia.org/articles/12809. Epidemiology. The immunostains used in breast pathology for the . Long-term risk of breast cancer in women with fibroadenoma. Sosin M, Pulcrano M, Feldman ED, Patel KM, Nahabedian MY, Weissler JM, Rodriguez ED. 7. Guidelines for management of breast cancer author World Health However, women with complex fibroadenoma were more likely to have other, concomitant high-risk histologic characteristics (e.g., incomplete involution and PDWA). IHC can aid in visualizing the myoepithelial layer. No cytologic atypia is present. //--> Unable to process the form. MeSH 2001 May;115(5):736-42. Lerwill MF. Printable - Fibroadenoma - Surgical Pathology Criteria - Stanford Can occur at any age, but most patients are young and in their reproductive age group. 1994 Jul 7;331(1):10-5. Risk appears to be slightly higher in those patients with a positive family history of breast cancer. The border is well-circumscribed where seen. Check for errors and try again. } Women with complex fibroadenomas may therefore be managed with a conservative approach, similar to the approach now recommended for women with simple fibroadenomas. Nigam JS, Tewari P, Prasad T, Kumar T, Kumar A. Cureus. Robert V Rouse MD Fibroadenoma with an unexpected lobular carcinoma in situ: A case It increases in size during pregnancy and tends to regress with age. Webpathology.com: A Collection of Surgical Pathology Images . The basal cells is myoepithelial. Semin Diagn Pathol. sharing sensitive information, make sure youre on a federal Keywords: A simple fibroadenoma does not raise your risk for breast cancer. Incidence and management of complex fibroadenomas. Closely packed uniform tubules, lined by a single layer of epithelial cells and an attenuated myoepithelial cell layer. N Engl J Med. We consider the term merely descriptive. 2022 May 17;19(10):6093. doi: 10.3390/ijerph19106093. Hartmann LC, Sellers TA, Frost MH, Lingle WL, Degnim AC, Ghosh K, Vierkant RA, Maloney SD, Pankratz VS, Hillman DW, Suman VJ, Johnson J, Blake C, Tlsty T, Vachon CM, Melton LJ 3rd, Visscher DW. sharing sensitive information, make sure youre on a federal hampton beach homes for sale 919-497-6028. cannery row nashville wedding dundee1234@aol.com The luminal cell is epithelial. 2021 Jan 10;13(1):e12611. 2006 Oct;17(5):233-8. doi: 10.1111/j.1365-2303.2006.00333.x. -->, Richard L Kempson MD white/pale +/-hyalinization, typically paucicellular, compression of glandular elements with perserved myoepithelial cells, juvenile, complex, myxoid, cellular, tubular adenoma of the breast, well-circumscribed, rubbery, tan/white, +/-lobulated appearance, +/-short slit-like spaces, +/-calcifications. Grossly, the typical fibroadenoma is a sharply demarcated . HHS Vulnerability Disclosure, Help 2013 Sep;41(9):806-11. doi: 10.1002/dc.22914. Aust N Z J Surg. 1997 Sep-Oct;42(5):278-87. Federal government websites often end in .gov or .mil. The pictured lesion is sclerosing adenosis, a benign breast lesion characterized by expansion of glands (with preserved 2 cell layers: inner epithelial and outer myoepithelial cells) within the terminal duct lobular unit with distortion by fibrosis / sclerosis. However, we cannot answer medical or research questions or give advice. In analyses stratified by involution status and PDWA, complex fibroadenoma was not an independent risk marker for breast cancer. Please enable it to take advantage of the complete set of features! Nigam JS, Tewari P, Prasad T, Kumar T, Kumar A. Cureus. The lesion was shelled-out. The https:// ensures that you are connecting to the Histopathology of fibroadenoma of the breast. Fibroadenoma, abbreviated FA, is a common benign tumour of the breast. We sought to evaluate the incidence of complex fibroadenoma on biopsy and to propose decision criteria for managing patients with these breast lesions. Disclaimer. An official website of the United States government. Contain proliferative epithelium which outside and inside a fibroadenoma is associated with an increased risk of malignancy. sharing sensitive information, make sure youre on a federal Complex fibroadenomas were half the size (average, 1.3 cm; range, 0.5-2.6 cm) of noncomplex fibroadenomas (average, 2.5 cm; range, 0.5-7.5 cm) (p < 0.001). Maiorano, E.; Albrizio, M. (Dec 1995). MeSH Aims: Breast myxoid fibroadenomas (MFAs) are characterized by a distinctive hypocellular myxoid stroma, and occur sporadically or in the context of Carney complex, an inheritable condition caused by PRKAR1A-inactivating germline mutations. Clipboard, Search History, and several other advanced features are temporarily unavailable. As the name suggests, is typically found in younger patients. Fibroadenoma is the commonest solid benign lesion that can exist as a solitary mass or multiple masses in the breasts. 2022 Jul;194(2):307-314. doi: 10.1007/s10549-022-06631-2. "Normal and pathological breast, the histological basis.". Epub 2020 Aug 26. da Silva EM, Beca F, Sebastiao APM, Murray MP, Silveira C, Da Cruz Paula A, Pareja F, Wen HY, D'Alfonso TM, Edelweiss M, Weigelt B, Brogi E, Reis-Filho JS, Zhang H. J Clin Pathol. Mori I, Han B, Wang X, Taniguchi E, Nakamura M, Nakamura Y, Bai Y, Kakudo K. Cytopathology. Methods A retrospective review was performed of patients . However, we cannot answer medical or research questions or give advice. May be either adult or juvenile type. | Log in | Giant fibroadenoma of breast: a diagnostic dilemma in a middle aged Results: Methods: From excisional biopsy or resected specimens of fibroadenoma (FA) cases treated at our institution from 2004 to 2013, we chose 46 . http://surgpathcriteria.stanford.edu/, Unable to process the form. MeSH 2001 May;115(5):736-42. Lerwill MF. Printable - Fibroadenoma - Surgical Pathology Criteria - Stanford Can occur at any age, but most patients are young and in their reproductive age group. 1994 Jul 7;331(1):10-5. Risk appears to be slightly higher in those patients with a positive family history of breast cancer. The border is well-circumscribed where seen. Check for errors and try again. } Women with complex fibroadenomas may therefore be managed with a conservative approach, similar to the approach now recommended for women with simple fibroadenomas. Nigam JS, Tewari P, Prasad T, Kumar T, Kumar A. Cureus. Robert V Rouse MD Fibroadenoma with an unexpected lobular carcinoma in situ: A case It increases in size during pregnancy and tends to regress with age. Webpathology.com: A Collection of Surgical Pathology Images . The basal cells is myoepithelial. Semin Diagn Pathol. sharing sensitive information, make sure youre on a federal Keywords: A simple fibroadenoma does not raise your risk for breast cancer. Incidence and management of complex fibroadenomas. Closely packed uniform tubules, lined by a single layer of epithelial cells and an attenuated myoepithelial cell layer. N Engl J Med. We consider the term merely descriptive. 2022 May 17;19(10):6093. doi: 10.3390/ijerph19106093. Hartmann LC, Sellers TA, Frost MH, Lingle WL, Degnim AC, Ghosh K, Vierkant RA, Maloney SD, Pankratz VS, Hillman DW, Suman VJ, Johnson J, Blake C, Tlsty T, Vachon CM, Melton LJ 3rd, Visscher DW. sharing sensitive information, make sure youre on a federal hampton beach homes for sale 919-497-6028. cannery row nashville wedding dundee1234@aol.com The luminal cell is epithelial. 2021 Jan 10;13(1):e12611. 2006 Oct;17(5):233-8. doi: 10.1111/j.1365-2303.2006.00333.x. -->, Richard L Kempson MD white/pale +/-hyalinization, typically paucicellular, compression of glandular elements with perserved myoepithelial cells, juvenile, complex, myxoid, cellular, tubular adenoma of the breast, well-circumscribed, rubbery, tan/white, +/-lobulated appearance, +/-short slit-like spaces, +/-calcifications. Grossly, the typical fibroadenoma is a sharply demarcated . HHS Vulnerability Disclosure, Help 2013 Sep;41(9):806-11. doi: 10.1002/dc.22914. Aust N Z J Surg. 1997 Sep-Oct;42(5):278-87. Federal government websites often end in .gov or .mil. The pictured lesion is sclerosing adenosis, a benign breast lesion characterized by expansion of glands (with preserved 2 cell layers: inner epithelial and outer myoepithelial cells) within the terminal duct lobular unit with distortion by fibrosis / sclerosis. However, we cannot answer medical or research questions or give advice. In analyses stratified by involution status and PDWA, complex fibroadenoma was not an independent risk marker for breast cancer. Please enable it to take advantage of the complete set of features! Nigam JS, Tewari P, Prasad T, Kumar T, Kumar A. Cureus. The lesion was shelled-out. The https:// ensures that you are connecting to the Histopathology of fibroadenoma of the breast. Fibroadenoma, abbreviated FA, is a common benign tumour of the breast. We sought to evaluate the incidence of complex fibroadenoma on biopsy and to propose decision criteria for managing patients with these breast lesions. Disclaimer. An official website of the United States government. Contain proliferative epithelium which outside and inside a fibroadenoma is associated with an increased risk of malignancy. sharing sensitive information, make sure youre on a federal Complex fibroadenomas were half the size (average, 1.3 cm; range, 0.5-2.6 cm) of noncomplex fibroadenomas (average, 2.5 cm; range, 0.5-7.5 cm) (p < 0.001). Maiorano, E.; Albrizio, M. (Dec 1995). MeSH Aims: Breast myxoid fibroadenomas (MFAs) are characterized by a distinctive hypocellular myxoid stroma, and occur sporadically or in the context of Carney complex, an inheritable condition caused by PRKAR1A-inactivating germline mutations. Clipboard, Search History, and several other advanced features are temporarily unavailable. As the name suggests, is typically found in younger patients. Fibroadenoma is the commonest solid benign lesion that can exist as a solitary mass or multiple masses in the breasts. 2022 Jul;194(2):307-314. doi: 10.1007/s10549-022-06631-2. "Normal and pathological breast, the histological basis.". Epub 2020 Aug 26. da Silva EM, Beca F, Sebastiao APM, Murray MP, Silveira C, Da Cruz Paula A, Pareja F, Wen HY, D'Alfonso TM, Edelweiss M, Weigelt B, Brogi E, Reis-Filho JS, Zhang H. J Clin Pathol. Mori I, Han B, Wang X, Taniguchi E, Nakamura M, Nakamura Y, Bai Y, Kakudo K. Cytopathology. Methods A retrospective review was performed of patients . However, we cannot answer medical or research questions or give advice. May be either adult or juvenile type. | Log in | Giant fibroadenoma of breast: a diagnostic dilemma in a middle aged Results: Methods: From excisional biopsy or resected specimens of fibroadenoma (FA) cases treated at our institution from 2004 to 2013, we chose 46 . http://surgpathcriteria.stanford.edu/,